Formulation And Evaluation of Flurbiprofen Matrix Tablets For Colon Targeting
نویسندگان
چکیده
The present study is the development of colon targeted matrix tablets of the drug flurbiprofen, a NSAIDS of the class of Ibuprofen designed to prolonged the release for sustained effect. Different formulation (F1 TO F9) batches were made with the help of different polymers and their different proportions (Guar Gum, Eudragit RL, Eudragit RS ) with the help of Wet granulation techniques. The prepared matrix tablets were evaluated in terms of their pre-compression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, invitro drug release. From this study we concluded that the batch F7 shows good results then the other batches. The batch F7 shows maximum prolong release upto 12 hrs.
منابع مشابه
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